Health & Wellness

Top 11 List of Foods to Avoid with Clopidogrel

Are you looking for list of Foods to Avoid with clopidogrel? Taking care of your health is so important, and one way to do that is by understanding how medications interact with our bodies. Clopidogrel, an antiplatelet medicine, can be very beneficial, but it’s also important to be aware of the foods that could interfere with its effectiveness or increase the risk of bleeding.

That’s why we’ve put together this comprehensive guide on a list of foods you should avoid or consume in moderation while taking clopidogrel medication. We hope this helps you make informed choices about your diet and optimize the benefits of clopidogrel for your overall well-being!

In This Article

List of Foods to Avoid with Clopidogrel

Foods to Avoid with Clopidogrel

Here we have listed what should you not take with clopidogrel

1. Grapefruit

When taking clopidogrel, avoiding grapefruit and grapefruit juice is best since they may affect how the medicine is metabolized.

Furanocoumarins in grapefruit prevent the liver’s CYP3A4 enzyme from functioning. This enzyme plays a crucial role in metabolizing many medications, including clopidogrel.

2. Pomegranate

Pomegranate contains compounds that can inhibit certain enzymes involved in drug metabolism, including the enzyme responsible for activating clopidogrel. Clopidogrel requires activation in the body to become effective in preventing blood clots.

When pomegranate juice or its constituents interfere with the activation process, it can reduce the effectiveness of clopidogrel.

3. Cranberry

Cranberry juice and supplements contain compounds called proanthocyanidins, which can inhibit platelet function. That means they make it harder for blood to clot. On the other hand, clopidogrel is an antiplatelet medication that works by preventing blood clots from forming.

When both are taken together, there could be a risk of increased bleeding because they have similar effects on the body.

4. Green Leafy Vegetables

We all know green leafy vegetables are generally healthy and provide various nutritional benefits. However, it’s important to be aware of the high levels of vitamin K they contain – too much can interfere with the anticoagulant effects of clopidogrel.

Clopidogrel is an antiplatelet medication used to prevent blood platelets from sticking together and forming clots, so we must monitor our intake of foods rich in vitamin K, like spinach, kale, or broccoli, if we are taking this medication

5. Garlic

Garlic has natural antiplatelet properties. This means it can thin the blood and inhibit platelet aggregation. Combined with medications like clopidogrel, which also have anticoagulant effects, there is an increased risk of bleeding.

So if you are on any medication or having surgery soon, then make sure to talk to your doctor about how much garlic intake is safe for you!

6. Ginger

It’s important to know the potential risks of taking ginger and clopidogrel together. Ginger contains compounds called gingerols with antiplatelet properties which can interfere with blood clotting when combined with clopidogrel.

7. Turmeric

Turmeric contains a compound called curcumin, which has been found to possess antiplatelet and anticoagulant properties. This means that it can interfere with the normal functioning of platelets, which are responsible for blood clotting.

8. Alcohol

It’s important to be aware that combining alcohol and clopidogrel can seriously affect your body. Alcohol is known to thin blood, which can increase the risk of bleeding.

When combined with clopidogrel – an antiplatelet medication designed to prevent blood clotting – this increased anticoagulant effect may lead to an even higher risk of excessive bleeding or bruising.

9. Licorice

As you may know, licorice contains a compound called glycyrrhizin, which can harm your health if consumed in large amounts. Glycyrrhizin can increase blood pressure and sodium retention in the body and potentially reduce the effectiveness of clopidogrel, an enzyme responsible for metabolizing it.

9. Omega-3 fatty acids

Did you know that Omega-3 fatty acids, commonly found in fish oil supplements and fatty fish like salmon, have blood-thinning properties? They can reduce platelet aggregation and decrease the ability of blood to clot. Clopidogrel is also an antiplatelet medication that prevents platelets from sticking together and forming clots.

10. Supplements and Herbal remedies

We all know that herbal remedies can be beneficial, but it’s important to remember that some of them, such as ginkgo biloba, ginger and St. John’s wort can interfere with clopidogrel.

That’s why it is always best to discuss any supplements or herbal remedies you are taking with your healthcare provider before using them.

11. Spicy foods

We all love a good spicy meal from time to time. While it’s generally safe to eat spicy foods when taking clopidogrel, there is always the potential that they may irritate your stomach lining and increase the risk of gastrointestinal bleeding.

So if you’re on clopidogrel and don’t want any additional risks, avoid overly-spicy dishes just in case!


It’s important to remember that when taking clopidogrel, certain foods can interfere with its effectiveness and increase the risk of bleeding.

While the list may vary depending on individual circumstances, consulting a healthcare provider or pharmacist is key for personalized advice regarding diet and medication interactions. They can provide recommendations based on your medical history and needs!


  1. Clopidogrel: a review of its use in the prevention of atherothrombosis
  2. Effect of food on bioavailability of a single oral dose of clopidogrel 
  3. (PDF) Pharmacokinetic drug interactions with clopidogrel

Dr Maria

MD. Board Certified physician. Fellowship In Family Medicine UK. 8 years of medical experience in Lifestyle-related health disorders. Graduated from AIIMS – All India Institute Of Medical Science, INDIA

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